Why Are So Many Celebrities on Weight-Loss Drugs Like Ozempic and Mounjaro?

The rise of celebrities on weight-loss drugs like Ozempic, Mounjaro, and Wegovy has sparked a public conversation about body image, health, and modern medicine. Celebs are turning to these medications for various reasons:

  • Oprah Winfrey uses it as a tool for stability, not shame.

  • Kelly Clarkson & Charles Barkley credit medical guidance.

  • Kathy Bates, Whoopi Goldberg, & Jim Gaffigan found success—but also worked hard.

  • Amy Schumer & Sharon Osbourne quit due to side effects.

  • Others, like Tracy Morgan and Elon Musk, embraced it with humor or advocacy.

The takeaway? These drugs can help, but results vary—and medical guidance is key.

Over the past couple of years, weight-loss medications like Ozempic, Mounjaro, and Wegovy have taken the world by storm. Originally designed to treat Type 2 diabetes, these medications—particularly their active ingredients like semaglutide—have gained attention for their dramatic weight-loss side effects. With social media flooded with before-and-after photos and whispers about celebrities using these weight-loss drugs, many are wondering: Who’s on the weight-loss medication bandwagon?

The buzz surrounding these drugs isn’t just limited to the general public. A growing number of celebrities have opened up about their experiences with weight-loss drugs like Ozempic and Mounjaro, either praising their effectiveness or candidly sharing the challenges they faced. Let’s take a look at the stars who’ve used these weight-loss tools—and what they’ve had to say about their journeys.

Oprah Winfrey: A Weight-Loss Journey Without Shame

Oprah Winfrey is no stranger to public discussions about her weight struggles. In December 2023, she revealed that she’s been using a weight-loss drug to help maintain her weight and avoid the dreaded “yo-yo effect.” While she didn’t disclose the exact medication, she described it as a “tool” and emphasized how it has provided her with a sense of relief from years of self-blame. “I’ve realized that no amount of willpower can control a predisposition,” she said. For Winfrey, it’s not about shame—it’s about health.

Kelly Clarkson: A Reluctant Start to a New Chapter

When Kelly Clarkson revealed that she was taking a weight-loss medication, she was quick to clarify that it wasn’t Ozempic. Instead, she credited a different drug that helped her regulate her blood sugar levels. “My doctor chased me for two years before I finally tried it,” she admitted. Clarkson has been open about her thyroid issues and her initial hesitation to try medication. Now, she praises the results, describing it as a much-needed intervention to improve her health.

Celebrities posing with weight-loss drug pens Ozempic and Mounjaro on an orange background.

Kathy Bates: Hard Work Meets Ozempic

Kathy Bates has lost 100 pounds over the past seven years, with some of that progress attributed to Ozempic. However, the award-winning actress insists that her journey was far from easy. “Even with Ozempic, I still have to pay attention to what I’m eating,” she said, emphasizing the importance of lifestyle changes alongside the medication.

Harvey Fierstein: A New Lease on Life with Zepbound

Broadway legend Harvey Fierstein has used Eli Lilly’s Zepbound (another GLP-1 receptor agonist) to shed an impressive 120 pounds. For Fierstein, the biggest difference has been the mental shift. “I don’t feel like I’m dieting—I feel like a normal person,” he said, sharing how the medication has helped him regain control over his eating habits.

Jim Gaffigan: Grateful for Mounjaro

Comedian Jim Gaffigan lost 50 pounds using Mounjaro, a medication he initially approached with skepticism. “I thought my love of food would overpower anything,” he joked, but the drug ended up surprising him. Gaffigan has since used his platform to destigmatize weight-loss medications, encouraging others to consider their health without judgment.

Want to know how to use Mounjaro to lose weight and control blood sugar? Find a full guide in the link with expert medical advice included.

James Corden: Ozempic Wasn’t the Answer

James Corden was another one of the celebrities who used weight-loss drugs. He gave Ozempic a shot but found it didn’t address the root of his eating habits. “I realized my eating wasn’t about hunger,” he shared on his podcast. While Corden didn’t see success with the drug, his honesty highlights the reality that weight-loss medications aren’t a one-size-fits-all solution.

To get into the bottom of it, we suggest that you compare:

Whoopi Goldberg: Losing Two People’s Worth of Weight

Whoopi Goldberg credits Mounjaro for helping her lose a significant amount of weight—so much, in fact, that she jokingly described it as shedding “almost two people.” Despite her success, Goldberg has maintained that her weight has never been a major issue for her, focusing instead on her overall health.

Tracy Morgan: A Comedic Take on Ozempic

Leave it to Tracy Morgan to keep things light. The comedian openly admitted to using Ozempic during an appearance on TODAY, cheekily calling it his secret weapon. “I ain’t letting it go!” he joked. However, Morgan later shared that he managed to “out-eat Ozempic,” regaining some weight after initially losing it.

Sharon Osbourne: Too Thin, Too Fast

Sharon Osbourne had mixed feelings about her experience with Ozempic. While she lost 42 pounds, she admitted that the weight loss was more extreme than she intended. The nausea she experienced while on the drug also made her reconsider its use. “I didn’t actually want to go this thin,” she explained.

Charles Barkley: A Game Changer

NBA legend Charles Barkley started his weight-loss journey at 355 pounds and has since lost 65 pounds with Mounjaro. He’s been vocal about the benefits of the drug and is now considering going back on it to lose an additional 15 pounds. “There’s no shoe size that fits all,” Barkley said, emphasizing the importance of finding what works for each individual.

Celebrities using weight-loss drugs Ozempic and Mounjaro.

Amy Schumer: Not Worth the Nausea

Amy Schumer tried Ozempic briefly but quickly decided it wasn’t for her. “I felt so sick I couldn’t even play with my son,” she said. Schumer has also been outspoken about the need for transparency among celebrities using weight-loss drugs, calling out others for not being honest.

Elon Musk: The Self-Proclaimed ‘Ozempic Santa’

Elon Musk is a vocal proponent of weight-loss drugs, though he clarified that he’s actually using Mounjaro rather than Ozempic. In true Musk fashion, he dubbed himself “Ozempic Santa” in a tongue-in-cheek social media post. Musk has also advocated for making these medications more affordable and accessible to the public.

Other Celebrities Who’ve Tried Weight-Loss Drugs

  • Heather Gay: The Real Housewives of Salt Lake City star embraced the “Ozempic train” and has seen noticeable results.
  • Chelsea Handler: Handler unknowingly tried Ozempic after her doctor prescribed it. Once she realized what it was, she decided to stop.
  • Remi Bader: The influencer shared that Ozempic initially helped her lose weight but worsened her binge eating once she stopped.
  • Claudia Oshry: Oshry openly embraced Ozempic, calling it the “easy route” but later admitted she was constantly hungry after going off the drug.
  • Lauren Manzo: The Real Housewives alum lost 30 pounds with Mounjaro and praised the drug for helping her develop healthier habits.
  • Golnesa ‘GG’ Gharachedaghi: The Shahs of Sunset star lost 28 pounds with Ozempic and described it as a game changer.
  • Jon Gosselin: The Jon & Kate Plus 8 star lost 32 pounds in just two months and credited the drug for helping him quit drinking.
  • Patti Stanger, Emily Simpson, and Dolores Catania have also joined the weight-loss drug trend, each sharing their unique experiences with medications like Ozempic and Mounjaro for weight loss.

A New Era in Weight Management

As more celebrities share their stories about weight-loss drugs, it’s clear that GLP-1 medications like Ozempic and Mounjaro have sparked a revolution in weight management. However, these drugs come with varying experiences, side effects, and challenges, reminding us that no single solution works for everyone. Whether it’s for health, confidence, or simply convenience, the decision to use these medications is deeply personal—and one that should always involve consulting a doctor.

The weight-loss drug craze is here to stay, and with it comes a greater dialogue about health, stigma, and the tools available to achieve lasting change.

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